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doi: 10.1001/jamanetworkopen.2020.19722 42 MessikaJ.SztrymfB.BertrandF.Billard-PomaresT.BarnaudG.BrangerC.et al
Transition metals such as iron, copper, and manganese, act as prooxidant agents, although copper is also essential for the antioxidant function of the protein ceruloplasmin, and copper and manganese are constituents of the cytosolic Cu +2 /Zn +2 and the mitochondrial Mn +2 -superoxide-dismutases (SOD, protective against oxidative processes)
Genome-wide analyses in cancer have unveiled widespread hypomethylation patterns in DNA, which when present, accompany the activation of transcription, repetitive sequences, transposable elements, and oncogenes, potentially leading to aneuploidy and genomic instability, hallmark features of cancer
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